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Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Sponsor: Joel Trinity
Summary
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and increased mortality. Older adults are a particularly vulnerable population as functional (vascular and skeletal muscle mitochondrial dysfunction) and structural deficits (loss in muscle mass leading to a reduction in strength) are a consequence of the aging process. The combination of inactivity and aging poses an added health threat to these individuals by accelerating the negative impact on vascular and skeletal muscle function and dysfunction. The underlying factors leading to vascular and skeletal muscle dysfunction are unknown, but have been linked to increases in oxidative stress. Additionally, there is a lack of understanding of how vascular function is impacted by inactivity in humans and how these changes are related to skeletal muscle function. It is our goal to investigate the mechanisms that contribute to disuse muscle atrophy and vascular dysfunction in order to diminish their negative impact, and preserve vascular and skeletal muscle function across all the lifespan.
Key Details
Gender
All
Age Range
65 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
72
Start Date
2019-09-01
Completion Date
2025-12-31
Last Updated
2025-04-23
Healthy Volunteers
Yes
Interventions
MITO-AO
Participants will receive 160 mg with breakfast on day 1 of bed rest and 40 mg with breakfast on days 2-5.
PB-125
Participants will receive 100 mg on days 1-5 of bed rest.
Placebo
Participants will receive Placebo on days 1-5 of bed rest.
Passive Leg Movement (PLM)
Participants will be tested for passive leg movement on baseline day 1, bed rest day 1, and post bed rest.
Plantar flexion
Participants will undergo plantar flexion on baseline day 2, pre bed rest, and post bed rest.
Isometric knee extensor test
Participants will undergo isometric knee extension on baseline day 2, pre bed rest, and post bed rest.
Bed rest
Participants will undergo 5 days bed rest after 5 day baseline assessments
Locations (1)
VA Medical Center
Salt Lake City, Utah, United States