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CBD-Microglia PET Study
Sponsor: Yale University
Summary
This study aims to examine the effect of cannabidiol (CBD) pre-treatment on brain microglial activation in healthy human subjects. Secondarily, this study aims to examine the effect of cannabidiol (CBD) pre-treatment on central pain-sensitization in healthy human subjects.
Official title: Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
Key Details
Gender
All
Age Range
18 Years - 55 Years
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2021-05-07
Completion Date
2025-09-30
Last Updated
2025-07-18
Healthy Volunteers
Yes
Interventions
[11C]PBR28
The radiotracer, \[11C\]PBR28, will be administered at the beginning of each PET scan
Low-dose lipopolysaccharide
Subjects will receive intravenous lipopolysaccharide.
Intradermal Capsaicin
A small dose of capsaicin will be administered by intradermal injection.
Locations (1)
Connecticut Mental Health Center
New Haven, Connecticut, United States