Clinical Research Directory

Inclusion Criteria: * 18-50y/o * Males and females of all races and ethnicities * Able to provide written informed consent * Able to read, speak, and understand English * Meet DSM-IV (SCID-based) criteria for schizophrenia, schizoaffective disorder, bipolar I disorder with psychotic features OR healthy controlled with no diagnosed severe mental illness * No history of adverse normal baseline values for liver function tests (LFTs) Exclusion Criteria: * Strongly left-handed individuals defined as a 60:40 or greater ratio of left to right hand preference (assessed using the Edinburgh Handedness Inventory) * Premorbid intellectual ability estimate below 70 (WRAT-4, Word Reading subtest, age-corrected standardized score) * Comorbid DSM-IV diagnosis of alcohol or substance abuse in prior 1 month or substance dependence in prior 3 months * Neurological (e.g., seizure disorder, stroke, traumatic brain injury with a loss of consciousness ≥ 30min) or severe medical condition (e.g., decompensated cardiovascular disorder, AIDS) that may affect central nervous system function * Concomitant medications that may interact with study drug adversely such as platelet inhibitors, benzodiazepines, or valproate * Initial detection of abnormal liver function tests or previous medical history of abnormal liver function or liver disease * Vulnerable populations (e.g., pregnant, nursing, incarcerated); unwilling to use reliable means of contraception * High risk for suicide defined as more than 1 attempt in past 12 months that required medical attention, any attempt in the past 3 months or current suicidal ideation with plan and intent such that outpatient care is precluded * Current homicidal ideation with plan and intent such that outpatient care is precluded * Positive result on breathalyzer or positive urine toxicology test for any substance, including CBD * History of prior allergic reaction with CBD or CBD-containing products