Clinical Research Directory

Inclusion criteria: 1. Severe COVID-19 , as defined by clinical signs indicative of severe systemic illness with COVID-19, being given oxygenation and meeting ONE of the following: Respiratory rate ≥ 30 per minute Heart rate ≥ 125 per minute SpO2 ≤ 93% on room air at sea level PaO2/FiO2 \< 300 mmHg or SpO2/FiO2 \< 315 mmHg 2. Positive test by standard RT-PCR assay or equivalent within last 7 days 3. Physician determination that patient is on SOC therapy, and will receive standard of care if patient progresses to Critical COVID-19, patient must be full CODE Exclusion criteria: 1. Evidence of Critical COVID-19 2. Inability to utilize nebulized drugs, or history of bronchospasm with inhaled medications 3. Age \<12 years; 4. Mean arterial pressure \< 65 mm Hg after initial hospital stabilization, 5. Non-COVID-19 irreversible underlying condition with projected fatal course within 6 months or with high risk of mortality; 6. Immunosuppressive treatment for transplant or other diseases associated with high mortality; 7. Stage IV cancer or cancer on active treatment with chemotherapy immunotherapy or checkpoint inhibitors; acute renal failure or chronic renal insufficiency with GFR less than 30; CHF New York Heart Association class III or IV, new neurologic disorder in the last 3 months or chronic neurologic disorder or other that would impact on assessing the resolution of severe COVID-19 respiratory failure 8. Myocardial Infarction in previous six months or troponin \>0.5 9. Recent history of venous thrombotic events (PE / DVT) within the last 3 months. 10. New diagnosis of atrial fibrillation within the last 3 months. Acceptable if greater than 3 months and well controlled in the opinion of the investigator 11. Watery diarrhea requiring replacement of 1 liter or more of iv fluids and electrolytes 12. Pregnancy