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Diaphragmatic Function as a Biomarker
Sponsor: RWTH Aachen University
Summary
Dyspnea is among the most common symptoms in patients with respiratory diseases such as Asthma, chronic obstructive pulmonary disease (COPD), Fibrosis, and Pulmonary Hypertension. However, the pathophysiology and underlying mechanisms of dyspnea in patients with respiratory diseases are still poorly understood. Diaphragm dysfunction might be highly prevalent in patients with dyspnea and respiratory diseases. The association of diaphragm function and potential prognostic significance in patients with respiratory diseases has not yet been investigated.
Official title: Diaphragmatic Function as a Biomarker in Patients With Respiratory Diseases
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
800
Start Date
2023-07-01
Completion Date
2026-12-30
Last Updated
2026-01-28
Healthy Volunteers
No
Interventions
Diaphragm Ultrasound
Ultrasound of the Diaphragm at the end of inspiration and expiration
Intercostal Muscle Ultrasound
Ultrasound of the Intercostal Muscles at the end of inspiration and expiration
Borg scale
Questionnaire for Perceived Exertion (Borg Rating of Perceived Exertion Scale)
MRC Breathlessness Scale
The MRC Dyspnoea Scale allows the patients to indicate the extent to which their breathlessness affects their mobility.
Respiratory Questionaire
Specialized respiratory questionnaire with different domains (Emotional Domain, Dyspnea Domain, Mastery Domain, Fatigue Domain)
GINA classification of Asthma
Patients are classified according to the GINA classification of Asthma.
Measurement of respiratory mouth pressure
Inspiratory and expiratory Measurement of respiratory mouth pressure
SNIP
Measurement of Sniff Nasal Inspiratory Pressure
6-minute walking distance
The maximum walking distance achieved in 6 minutes
60 seconds sit-to-stand test
number of repetitions achieved in sitting down and standing up in 60 seconds
Electromyography
electromyography of the muscles of respiration via superficial electrodes
Lung Function
Measurement of lung function via body plethysmography
CAT-Questionnaire
COPD Assessment Test (CAT)
European Society of Cardiology (ESC)/ European Respiratory Society (ERS) risk group
Patients with pulmonary hypertension are classified according to the ESC/ERS risk group.
Locations (1)
RWTH Aachen University Hospital
Aachen, North Rhine-Westphalia, Germany