Clinical Research Directory

Inclusion Criteria: * Men and women age range 65-75 years * Normal cognition (see Research Strategy for details on cognitive assessments) * "Healthy" (body mass index (BMI) of 20-40 kg/m2) Exclusion Criteria: * Significant cognitive or behavioral impairment (see Research Strategy for testing and exclusions) or pharmacological treatment for this (e.g. antipsychotics, anxiolytics, and sedative medications). * Hormone replacement therapy, past 3 months. * Hyper-androgenic condition. * HbA1C≥7.5% and or Fasting plasma glucose concentration ≥130 mg/dL. * Type 2 Diabetes if receiving any other therapy than metformin. * Use of nicotine or ingestion of caffeine or alcohol during the study. * Habitual fat intake \< 25% of kcal or strict vegetarian diet. * Sleep apnea requiring continuous positive airway pressure at night. * Lung, cardiac (heart failure or its treatment), liver disease, renal disease, cancer, and any other medical disorder known or thought to cause inflammation or abnormalities of cognition * Actively training for an athletic event or participating in competitive sports (such as league play or tournaments) * Intolerance or allergy to any of the food provided in the study.