Clinical Research Directory

Inclusion Criteria: * Must be a local adult resident of Macau * Age above 50 years for older adult cohort * Younger adults individuals above 18 will be included as control comparators Exclusion Criteria: * History of neurological injury or disease * Current use of medications that affect brain function or blood flow * Contraindications to MRI scanning, such as the presence of an electric/mechanical implant or device (e.g., pacemaker) * Claustrophobia * Body weight over 300 lbs due to weight and physical constraints of the scanner (i.e., bore size limited to 55 cm) * Inability to provide informed consent * Pregnancy * Being under the legal age of adulthood (children) * Incarcerated individuals (prisoners)