Clinical Research Directory
Browse clinical research sites, groups, and studies.
Systems Analysis and Improvement Approach to Prevent TB
Sponsor: Boston College
Summary
This randomized trial uses the evidence-based Systems Analysis and Improvement Approach (SAIA) adapted for tuberculosis (SAIA-TB) to assess the comprehensive tuberculosis (TB) care cascade across 16 clinics in rural Eastern Cape, South Africa to improve patient outcomes. The aims of this study are to: * Evaluate the effectiveness of SAIA-TB use in clinics on TB cascade outcomes for TB patients and with high-risk contacts * Determine the drivers of SAIA-TB implementation success or failure across clinics The investigators hypothesize that SAIA-TB implementation will lead to a 20% increase in each of: TB screening, TB preventive treatment initiation, and TB disease treatment initiation during the 18-month intervention period.
Official title: SAIA-TB: Using the Systems Analysis and Improvement Approach (SAIA) to Prevent TB in Rural South Africa
Key Details
Gender
All
Age Range
0 Years - Any
Study Type
INTERVENTIONAL
Enrollment
19560
Start Date
2025-02-06
Completion Date
2029-02-28
Last Updated
2025-05-06
Healthy Volunteers
No
Conditions
Interventions
Systems Analysis and Improvement Approach for TB (SAIA-TB)
The Systems Analysis and Improvement Approach for TB (SAIA-TB) is a five-step systems analysis and iterative improvement cycle intervention which will be implemented by clinic staff with support from study personnel in intervention clinics. Components of the intervention include TB cascade analysis, patient flow mapping and continuous quality improvement, aimed to incrementally optimize TB screening, evaluation, diagnosis, TB preventive therapy and TB disease treatment initiation, successful treatment, and TB-free survival among the population at the intervention clinics.
Locations (16)
Addo Clinic
Addo, South Africa
Lukhanyiso Clinic
Addo, South Africa
Kwa-Nonqubela Clinic
Alexandria, South Africa
Marselle Clinic
Boesmansriviermond, South Africa
Masakhane Clinic
Hankey, South Africa
Humansdorp Clinic
Humansdorp, South Africa
Pellsrus Clinic
Jeffrey's Bay, South Africa
Joubertina CHC
Joubertina, South Africa
Louterwater Clinic
Joubertina, South Africa
Twee Riviere Clinic
Joubertina, South Africa
Kareedouw Clinic
Kareedouw, South Africa
Kenton On Sea Clinic
Kenton on Sea, South Africa
Kirkwood Clinic
Kirkwood, South Africa
Moses Mabida Clinic
Kirkwood, South Africa
Imizamo Yetho Clinic
Patensie, South Africa
Nkwenkwezi Clinic
Port Alfred, South Africa