Clinical Research Directory

Inclusion Criteria: 1. Sufficient knowledge of English to understand and provide informed consent 2. Competent to provide consent 3. Aged 55-85, Male and Female 4. ≥ 8 years of education 5. Capable of cooperating for the duration of the study procedures and assessments 6. No frank cognitive impairment or dementia 7. Sufficient (corrected) vision to participate in cognitive testing 8. Sufficient (corrected) hearing to participate in cognitive testing Exclusion Criteria: 1. Cannot read and comprehend English language instructions 2. Major cardio- or cerebro-vascular event (heart attack, stroke, significant white matter changes) 3. Unstable diseases (e.g., pulmonary, endocrine disorder) 4. Active malignancy or infectious diseases 5. History of significant learning disability 6. Major psychiatric/neurologic/degenerative disorder, including a diagnosis of mild cognitive impairment or dementia 7. History of significant head trauma or recurrent concussions requiring hospitalization followed by persistent neurologic defaults or known structural brain abnormalities 8. Pain or sleep disorder that could interfere with cognitive testing 9. Major medical concerns that might interfere with cognitive testing 10. Recent history of substance/drug abuse 11. Known nickel allergy 12. Known cardiac implantable device 13. Known arrhythmias 14. Outside the included age range 15. Pregnant or breast feeding 16. Otherwise unable to use the ANNE sensors; for example, finger amputations.