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Transient Receptor Potential Channels
Sponsor: Penn State University
Summary
Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.
Official title: Transient Receptor Potential Channels in Human Skin
Key Details
Gender
All
Age Range
18 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2024-07-17
Completion Date
2026-12-31
Last Updated
2025-01-17
Healthy Volunteers
Yes
Conditions
Interventions
TRPM8 Agonist
menthol gel 4-10%
TRPV1 Agonist
camphor gel 5-20%
TRPV4 Agonist
capsaicin gel 0.05-1%%
TRPM8, TRPV4, TRPV1 Agonists
menthol (4-10%), capsaicin (0.05-1%), camphor (5-20%)
Vehicle gel
Inactive vehicle gel
Locations (1)
Noll Laboratory
University Park, Pennsylvania, United States