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Fiber and Calcium Absorption in Older Men
Sponsor: VA Office of Research and Development
Summary
Osteoporotic fractures are a major but underrecognized problem in men. There is growing evidence that low dietary fiber intake is a modifiable risk factor for age-related bone loss in men. Preclinical and human studies in adolescents and postmenopausal women suggest that dietary fiber intake influences bone metabolism by modulating the gut microbiome to augment intestinal calcium absorption, but it is unclear through what molecular mechanism and whether dietary fiber has the same effects in older men. In this crossover intervention study, the investigators will enroll and follow 30 older male Veterans to evaluate the effects of soluble corn fiber on intestinal calcium absorption and explore the contribution of the gut microbiome.
Official title: Modulation of the Gut Microbiome by Dietary Fiber to Improve Calcium Absorption and Bone Health in Older Men
Key Details
Gender
MALE
Age Range
60 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-01-01
Completion Date
2029-01-01
Last Updated
2026-02-17
Healthy Volunteers
Yes
Conditions
Interventions
Soluble corn fiber
Soluble corn fiber, also referred to resistant maltodextrin, is a type of dietary fiber made from corn starch. Soluble corn fiber is typically used to thicken processed foods and has been marketed as a prebiotic to improve digestive health.
Locations (1)
San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States