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DNA Methylation Trajectories in Aging
Sponsor: University of Campania Luigi Vanvitelli
Summary
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
Official title: EPIGENETIC-SENSITIVE BIOMARKERS OF INFLAMMAGING FROM HEALTHY TO HEART FAILURE DISEASE
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2024-11
Completion Date
2025-11
Last Updated
2024-09-03
Healthy Volunteers
No
Conditions
Interventions
RRBS
Measure of genomic regions with differentially methylated profiles and differentially expressed protein
Locations (1)
University of Campania Luigi Vanvitelli
Naples, No States Available, Italy