Clinical Research Directory

Inclusion Criteria: * Diagnosed COPD (post- bronchodilator FEV1/FVC \< 0.7) * 40\~80 years * CAT≥10 * At least two moderate or at least one severe exacerbation history in past 1 year * Able to sign informed consent Exclusion Criteria: * Continuous triple inhalation therapy for ≥6 months at baseline (include single inhaler and multiple inhalers) * Stable COPD (symptom such as cough, sputum and shortness of breath are mild or stable, clinical condition has basically returned to pre-exacerbation) * Comorbidities require/contraindicate long-term use of glucocorticoid treatment: asthma, interstitial lung disease, sarcoidosis, cystic fibrosis, active tuberculosis recurrent aspiration pneumonia ect. * Serious comorbidities threaten to life expected survival time no more than 1 year: severe heart disease, severe chronic liver, severe kidney disease, cerebrovascular disease with long-term bed rest and malignant tumours ect. * Not living in the healthcare area * Patients currently participating in any other interventional studies