Clinical Research Directory

Inclusion Criteria: * no history of regular physical activity training and exercise of more than 150 minutes of moderate or 75 minutes of higher intensity per week. * Body mass index (BMI) between 18.5 and 30 kg/m2 for all groups Exclusion criteria for probands will be: * Recent or current infection, physical disability, * malignant, cardiovascular, metabolic, autoimmune diseases, * Malnutrition and pharmacological interference (e.g., steroids, non-steroidal anti-inflammatory agents, immunosuppressive and antineoplastic drugs). Use of performance enhancing drugs in the past and during the study period will condition exclusion. Exclusion Criteria: * recent or current infection, physical disabilities, * malignant, cardiovascular, metabolic, autoimmune diseases, * Malnutrition and pharmacological interference (e.g., steroids, nonsteroidal anti-inflammatory agents, immunosuppressive and antineoplastic drugs). Use of performance-enhancing drugs in the past and during the study period will condition exclusion.