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NCT06768112
NA

Non-Invasive Vagus Nerve Stimulation Combine Postural Training in the Elderly

Sponsor: National Cheng-Kung University Hospital

View on ClinicalTrials.gov

Summary

This three-year research proposal aims to enhance postural control in older adults using non-invasive vagus nerve stimulation (nVNS). The study will develop a new system integrating cerebellar EEG (ECeG), EEG, and ECG to assess how nVNS combined with postural training affects individuals with early-stage frontal degeneration. In the first year, the focus will be on creating and validating the ECeG system to explore neural mechanisms of postural control. The second year will test the combined effects of ear-nVNS and dynamic posture training, examining how nVNS influences adrenal and hormone pathways. The final year will evaluate if ear-nVNS can further improve postural training with virtual feedback. Overall, the project aims to advance fall prevention strategies for older adults by exploring the role of cerebellar function and innovative training methods.

Official title: Adaptive Changes in Plasticity of Cerebrum and Cerebellum Following Innovative Postural

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

144

Start Date

2024-08-01

Completion Date

2027-12-31

Last Updated

2025-01-10

Healthy Volunteers

Yes

Conditions

Interventions

DEVICE

Non-Invasive Vagus Nerve Stimulation

Using non-invasive vagus nerve stimulation at the ear to stimulate the adrenergic and serum hormone pathways, activating the frontal lobe system, sensory-motor nervous system, and cerebellum, to investigate the effects and neural mechanisms of dynamic posture training and learning.

BEHAVIORAL

balance training

Participants will be asked to stand on a soft-platform and hit on blaze-pod LED within 60 seconds.

BEHAVIORAL

Mini-Mental State Examination

The mini-mental state examination (MMSE) or Folstein test is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment.

Locations (1)

National Chen Kong University Hospital

Tainan, Taiwan