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Non-Invasive Vagus Nerve Stimulation Combine Postural Training in the Elderly
Sponsor: National Cheng-Kung University Hospital
Summary
This three-year research proposal aims to enhance postural control in older adults using non-invasive vagus nerve stimulation (nVNS). The study will develop a new system integrating cerebellar EEG (ECeG), EEG, and ECG to assess how nVNS combined with postural training affects individuals with early-stage frontal degeneration. In the first year, the focus will be on creating and validating the ECeG system to explore neural mechanisms of postural control. The second year will test the combined effects of ear-nVNS and dynamic posture training, examining how nVNS influences adrenal and hormone pathways. The final year will evaluate if ear-nVNS can further improve postural training with virtual feedback. Overall, the project aims to advance fall prevention strategies for older adults by exploring the role of cerebellar function and innovative training methods.
Official title: Adaptive Changes in Plasticity of Cerebrum and Cerebellum Following Innovative Postural
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
144
Start Date
2024-08-01
Completion Date
2027-12-31
Last Updated
2025-01-10
Healthy Volunteers
Yes
Interventions
Non-Invasive Vagus Nerve Stimulation
Using non-invasive vagus nerve stimulation at the ear to stimulate the adrenergic and serum hormone pathways, activating the frontal lobe system, sensory-motor nervous system, and cerebellum, to investigate the effects and neural mechanisms of dynamic posture training and learning.
balance training
Participants will be asked to stand on a soft-platform and hit on blaze-pod LED within 60 seconds.
Mini-Mental State Examination
The mini-mental state examination (MMSE) or Folstein test is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment.
Locations (1)
National Chen Kong University Hospital
Tainan, Taiwan