Clinical Research Directory

Inclusion Criteria: * Patients aged \> 40 years of either sex; * BMI \>18.5 * COPD diagnosis according to the GOLD \[2021 Global initiative for chronic obstructive lung disease\] classification in the stable stage; * Signing of informed consent after receiving all information about the study. Exclusion Criteria: * COPD not stabilized at the time of enrollment; * BMI \< 18.5 * presence of tracheostomy * uncontrolled hypertension (systolic blood pressure \> 160 mmHg, diastolic \> 100 mmHg); * hypotension (systolic blood pressure \<100 mm Hg); * Significant comorbidities that limit exercise tolerance; * intercurrent infectious diseases, including HIV diagnosis; * Patients diagnosed with malignancy in progress or in remission for less than 5 years; * patients diagnosed with severe neurological, rheumatologic, or musculoskeletal diseases; * patients with a history of thoracic surgery; * presence of severe aortic stenosis, uncontrolled atrial/ventricular arrhythmia, recent cardiac ischemic event; * cognitive impairment conditions that prevent full understanding of the study protocol (mental retardation, dementia, etc.) and/or adequate test performance compliance; * failure to sign informed consent; * any other serious medical condition that may interfere with data interpretation and safety or that may make the respiratory rehabilitation course difficult, limited, or uncomfortable.