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Pre-malignant States to Hematologic Malignancies in Firefighters
Sponsor: Wake Forest University Health Sciences
Summary
The purpose of the study is to evaluate if firefighter exposure to hazardous compounds will increase the incidence of premalignant hematological states which subsequently increases the risk of the development of hematologic malignancies, and potentially other pathophysiological consequences.
Key Details
Gender
All
Age Range
40 Years - 49 Years
Study Type
OBSERVATIONAL
Enrollment
300
Start Date
2026-03
Completion Date
2027-04
Last Updated
2026-01-21
Healthy Volunteers
Yes
Conditions
Interventions
Monoclonal Gammopathy
Whole blood will be collected at the Baseline visit to evaluate for monoclonal gammopathy through SPEP, immunofixation, and free light chains.
Complete Blood Count with differential (CBC w/ diff)
Whole blood will be collected at the Baseline visit for CBC with differential which may inform a diagnosis of a plasma cell disorder or other hematological disorder.
Clonal hematopoiesis (CHIP)
Whole blood will be collected at the Baseline visit to be evaluated using next generation sequencing (NGS) detection of CHIP. Deep NGS to identify mutations associated with myeloid neoplasms and CHIP will be performed using an error-correcting next generation sequencing multi-gene panel targeting genes most frequently mutated in CHIP.
Locations (1)
Levine Cancer Institute
Charlotte, North Carolina, United States