Clinical Research Directory

Inclusion Criteria: * Non-smokers * Signed informed consent * Presence of subjective or mild cognitive impairment (SCI/aMCI) * Elevated levels of selected biomarkers confirming the presence of a pathological process characteristic of Alzheimer's disease * Absence of any psychological, sociological, or geographical factors that could jeopardize participation in the project. Exclusion Criteria: * Presence of severe cardiovascular, liver, or kidney diseases; advanced or poorly controlled diabetes mellitus (HbA1c \>7%), treated with insulin or incretin analogs; cancer or any other severe disease as assessed by the responsible physician. A history of cancer treated with chemotherapy or radiotherapy if within less than 5 years post-treatment. * Lack of cooperation, inflexible schedule, or problematic transportation. * Insufficient functional capacity or presence of comorbidities that prevent participation in the training program (assessment by an internist, cardiologist, neurologist, orthopedic specialist, or other relevant specialists). * Presence of a pacemaker or any metal implants (contraindication for MRI examination), or allergy to local anesthetics (contraindication for muscle biopsy). * Smoking, alcohol dependence, or addiction to other narcotic substances. * Stroke or myocardial infarction within the last year. * Long-term treatment for psychiatric disorders - a depressive syndrome is not an exclusion criterion if it is compensated by therapy. * Other diseases of the musculoskeletal or nervous system that potentially interfere with the ability to exercise or cognition - such as severe arthritis, Parkinson's disease, significant essential tremor, epilepsy, etc. * Concurrent participation in another clinical study. * Therapy with cholinesterase inhibitors unless the patient is on a stable dose.