Clinical Research Directory

Participants must be residents of Illinois or Missouri and able to come to St. Louis offices in person. Inclusion Criteria: * Ages 50-70 * Able to come to the research center for testing and intervention visits. * Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)). * BMI≥27 or Body Roundness index ≥6 * Able to provide informed consent. Exclusion Criteria: * Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records. * Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation. * Unable to perform study assessments. * Alcohol or substance abuse within 6 months per self-report or medical records. * Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity. * Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine) * PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention