Clinical Research Directory

Inclusion Criteria: * Aged ≥18 years * Stable clinical condition for \>3 weeks (e.g., no exacerbations) * Resting SpO₂ ≥88% and exercise-induced hypoxemia defined as a drop in SpO₂ of ≥4% and/or a level below 90% during the 6MWT * Informed consent documented by signature Exclusion Criteria: * Severe daytime resting hypoxemia (SpO₂ \<88%) * Long-term oxygen therapy * Unstable clinical condition requiring adjustment of pharmacological or other treatment modalities, need for intensive care, or presence of relevant severe comorbidities * Inability to comply with study procedures (e.g., due to language barriers, psychological disorders, neurological or orthopedic impairments, walking disability, or inability to ride a bicycle) * Women who are pregnant or breastfeeding * Enrolment in another clinical trial involving active treatment