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Restructuring the Alpha-Gamma Code in Aging Vision
Sponsor: Boston University Charles River Campus
Summary
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-troughs" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.
Official title: Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-01-10
Completion Date
2030-08-31
Last Updated
2025-10-06
Healthy Volunteers
Yes
Interventions
High definition transcranial electrical current stimulation
Low-intensity and safe, noninvasive application of electrical current to the human scalp with the goal of gradually modulating levels of neuronal excitability.