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Restructuring the Alpha-Gamma Code in Aging Vision
Sponsor: Boston University Charles River Campus
Summary
Tests whether age-related visual deficits arise from disrupted alpha-gamma coupling in visual cortex (V1) and MT. Uses fMRI, source-resolved HD-EEG, and personalized complex-waveform HD-tACS to (1) quantify aging effects on phase-amplitude coupling, (2) drive PAC into a preferred "gamma-at-alpha-troughs" state, and (3) bidirectionally change perception by aligning gamma to alpha troughs vs peaks. Two five-day, double-blind, sham-controlled studies (n=120 each) target contrast sensitivity (V1) and 3D shape-from-motion (MT), aiming for mechanistic insight and remediation in older adults with implications for ADRD.
Official title: Rescuing Visual Perception in Aging Adults by Restructuring the Alpha-Gamma Neural Code
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
240
Start Date
2026-04-02
Completion Date
2030-08-31
Last Updated
2026-07-16
Healthy Volunteers
Yes
Interventions
High definition transcranial electrical current stimulation
Low-intensity and safe, noninvasive application of electrical current to the human scalp with the goal of gradually modulating levels of neuronal excitability.
Locations (1)
111 Cummington Mall, Boston University
Boston, Massachusetts, United States