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Topical Imiquimod Treatment of Oral Dysplasia
Sponsor: University of Southern California
Summary
The goal of this clinical trial is to determine the effectiveness of imiquimod in treating oral dysplasia in adult patients. Imiquimod 5% cream could be a safe and practical treatment for oral epithelial dysplasia (a precancerous change in the mouth). The main questions it aims to answer are: 1. Does imiquimod help to make the lesions smaller and make the abnormal cell changes less severe? 2. How can we make this treatment safer and more feasible? Participants will apply topical imiquimod cream to treat the oral dysplasia and receive two follow-up biopsies after the treatment.
Official title: Topical Imiquimod for the Treatment of Oral Dysplastic Lesions With Clinical and Histologic Assessments
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-10-01
Completion Date
2027-10-01
Last Updated
2026-03-04
Healthy Volunteers
No
Interventions
Imiquimod (topical use)
Participants will be prescribed imiquimod 5% cream, with instructions to apply the cream with soft tray or gauze daily for one hour, five days a week (Monday to Friday). 6 week as one course and additional course may be added based on participant's conditions and consent. 2 follow up biopsies are scheduled 6 months and 12 months after the start of the treatment course.
Locations (1)
OralCare PreCancer and Pain Clinic
Los Angeles, California, United States