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Neuroimaging of Adolescent Cannabis Use Treatment
Sponsor: Indiana University
Summary
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use. Teens ages 14-17 will complete a brain scan and then take part in 10 weekly virtual sessions where they report cannabis use and complete drug tests at home. Participants can earn prizes for staying cannabis-free.
Official title: Neuroimaging of Instrumental Learning Networks in Adolescent Cannabis Use Treatment
Key Details
Gender
All
Age Range
14 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
80
Start Date
2026-04
Completion Date
2030-07
Last Updated
2026-03-27
Healthy Volunteers
No
Conditions
Interventions
Contingency Management
Contingency management is an evidence-based behavioral intervention used to treat substance use disorders, including cannabis use disorder (CUD). Contingency management operates on the principles of instrumental learning, where positive reinforcement is used to encourage desired behaviors, such as abstinence from cannabis. First, specific target behaviors are identified for reinforcement. In CUD, this is often abstinence from cannabis use, verified through regular urine drug screens and self-reports. If the target behavior (i.e., abstaining from cannabis for a specified time period) is achieved, then patients receive tangible rewards immediately after attaining the target behavior. These rewards are often in the form of money, vouchers, or other incentives that are meaningful to the individual. We will examine whether success during contingency management treatment for cannabis use is associated with neural activity during instrumental learning in N=80 adolescents ages 14-17.
Elastic Net Regression
We will apply an elastic net regression model to the neuroimaging data to estimate CUDIT score based on neuroimaging data.
Locations (1)
Indiana University School of Medicine
Indianapolis, Indiana, United States