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COMPLETED
NCT07383571
NA

Oral Hyoscine vs Lidocaine-Prilocaine Spray vs Placebo for HSG Pain Relief

Sponsor: Cairo University

View on ClinicalTrials.gov

Summary

This single-centre, three-arm, randomised, double-blind, double-dummy, placebo-controlled trial evaluated the efficacy and safety of oral hyoscine butylbromide, topical lidocaine-prilocaine spray and placebo for reducing pain during hysterosalpingography in women with primary infertility. Pain was self-rated using an 11-point numerical rating scale at predefined procedural time points, including cervical instrumentation and uterine filling.

Official title: Oral Hyoscine Butylbromide Versus Topical Lidocaine-Prilocaine Spray Versus Placebo for Pain Relief During Hysterosalpingography: A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Trial

Key Details

Gender

FEMALE

Age Range

18 Years - 40 Years

Study Type

INTERVENTIONAL

Enrollment

102

Start Date

2025-10-03

Completion Date

2026-04-30

Last Updated

2026-06-11

Healthy Volunteers

No

Interventions

DRUG

Oral Hyoscine butylbromide and Placebo Spray

Hyoscine butylbromide 20 mg oral tablet, single dose, administered 30 minutes before HSG, plus placebo cervical spray applied to the ectocervix and external cervical os 10 minutes before HSG.

DRUG

Topical lidocaine-prilocaine spray and placebo oral tablet

Topical lidocaine-prilocaine spray, Manovipercaine Plus, EVA Pharma, Egypt, containing lidocaine 15% and prilocaine 5%, applied as three sprays to the ectocervix and external cervical os 10 minutes before HSG, plus placebo oral tablet administered 30 minutes before HSG.

DRUG

Double Placebo

Placebo oral tablet administered 30 minutes before HSG plus placebo cervical spray applied 10 minutes before HSG, at the same time points as the active interventions.

Locations (1)

Algezeera Hospital

Giza, Egypt