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Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -
Sponsor: Research Center Borstel
Summary
The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections. By analyzing a single blood sample, the study examines how certain immune cells react during inflammation and infection, and whether lasting changes in these cells influence how strongly the body responds to disease. Although participants do not receive direct medical benefit, the results may help improve future diagnosis and treatment of lung diseases by providing deeper insight into immune responses.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2026-02-01
Completion Date
2030-12
Last Updated
2026-02-04
Healthy Volunteers
No
Interventions
Characterization of the neutrophil granulocyte epigenome
Characterization of epigenomic differences in neutrophils from patients with different lung diseases (asthma, COPD, pneumonia, tuberculosis, and viral pulmonary infections such as COVID-19 and influenza) by identifying disease-specific epigenetic and functional signatures
Characterization of the T-cell immune response to to various oxidatively modified mycobacterial antigens
Investigation of the response (activation/stimulation) of antigen-specific T cells from patients with tuberculosis to various oxidatively modified mycobacterial antigens, with the aim of determining whether changes in the redox status of these antigens measurably influence the adaptive immune response.
Locations (2)
Medical Service Center MVZ, Research Center Borstel, Leibniz Lung Center
Borstel, Schleswig-Holstein, Germany
Department of Pulmonology, University Hospital Schleswig-Holstein
Kiel, Schleswig-Holstein, Germany