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NOT YET RECRUITING
NCT07386912

Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -

Sponsor: Research Center Borstel

View on ClinicalTrials.gov

Summary

The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections. By analyzing a single blood sample, the study examines how certain immune cells react during inflammation and infection, and whether lasting changes in these cells influence how strongly the body responds to disease. Although participants do not receive direct medical benefit, the results may help improve future diagnosis and treatment of lung diseases by providing deeper insight into immune responses.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

100

Start Date

2026-02-01

Completion Date

2030-12

Last Updated

2026-02-04

Healthy Volunteers

No

Interventions

OTHER

Characterization of the neutrophil granulocyte epigenome

Characterization of epigenomic differences in neutrophils from patients with different lung diseases (asthma, COPD, pneumonia, tuberculosis, and viral pulmonary infections such as COVID-19 and influenza) by identifying disease-specific epigenetic and functional signatures

OTHER

Characterization of the T-cell immune response to to various oxidatively modified mycobacterial antigens

Investigation of the response (activation/stimulation) of antigen-specific T cells from patients with tuberculosis to various oxidatively modified mycobacterial antigens, with the aim of determining whether changes in the redox status of these antigens measurably influence the adaptive immune response.

Locations (2)

Medical Service Center MVZ, Research Center Borstel, Leibniz Lung Center

Borstel, Schleswig-Holstein, Germany

Department of Pulmonology, University Hospital Schleswig-Holstein

Kiel, Schleswig-Holstein, Germany