Clinical Research Directory
Browse clinical research sites, groups, and studies.
Comparison of the Effects of Moderate- and High-Dose Glucocorticoids on Postoperative Recovery
Sponsor: Ankara City Hospital Bilkent
Summary
Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems. Glucocorticoids such as dexamethasone are widely used in perioperative care for the prevention of postoperative nausea and vomiting and as part of multimodal analgesia strategies. This prospective randomized controlled trial aims to compare the effects of moderate- and high-dose intravenous dexamethasone administered intraoperatively on postoperative recovery in patients undergoing elective laparoscopic cholecystectomy. The primary outcomes include postoperative nausea and vomiting, inflammatory markers (CRP and WBC), and Quality of Recovery-15 (QoR-15) scores. Secondary outcomes include postoperative pain scores, intraoperative remifentanil consumption, postoperative opioid consumption, and adverse events.
Official title: Comparison of the Effects of Moderate- and High-Dose Glucocorticoid Administration on Postoperative Recovery: A Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
135
Start Date
2026-03-30
Completion Date
2026-07-30
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
Saline (0.9% NaCl)
Intravenous normal saline 4 mL administered intraoperatively to S group
TAP Block
Oblique subcostal TAP block is administered to all groups
moderate dose Dexamethasone
Intravenous dexamethasone administered intraoperatively at 0.1 mg/kg (D1)
High dose dexamethasone
Intravenous dexamethasone administered intraoperatively at 0.2 mg/kg (D2; maximum 20 mg).
Locations (1)
Ankara Bilkent City Hospital Department of Anesthesiology and Reanimation
Ankara, Çankaya, Turkey (Türkiye)