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Combination Gerotherapeutic Interventions for Healthspan Improvement
Sponsor: AgelessRx
Summary
This study is a 90-day interventional, randomized, controlled pilot trial exploring multi-modal gerotherapies and their impact on longevity-related outcomes. In this proof-of-concept phase, a small sample size of up to 30 subjects (10 subjects in each arm) will be randomized into one of the three arms: 1) Control, 2) Multi-therapy (B12, Naltrexone, Metformin, and NAD+), or 4) Comprehensive Therapy (Rapamycin, Naltrexone, Metformin, B12, NAD+, GSH, and Infinite Supplement).
Official title: A Pilot Randomized Controlled Study of Combinatorial Gerotherapeutics for Healthspan Improvement
Key Details
Gender
All
Age Range
60 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-07-23
Completion Date
2026-04
Last Updated
2026-03-16
Healthy Volunteers
Yes
Conditions
Interventions
Rapamycin
In the comprehensive therapy group, participants will start LDR at 2mg once per week and titrate up weekly to 6mg once per week.
Naltrexone
In both intervention groups, participants will start LDN at 1.5mg once daily and titrate up each week to 4.5mg daily.
Metformin
In both intervention groups, participants will take Metformin at 500mg daily.
NAD+
In both intervention groups, NAD+ will be taken as a nasal spray of 30mg/day.
GSH
In the comprehensive therapy group, GSH will be taken as a topical patch for 4 hrs, once per week.
Infinite Supplement
Participants in the comprehensive therapy group will take the Infinite supplement once daily. The Infinite supplement is a proprietary blend of seven putative geroprotective compounds implicated in enhancing cellular function critical for managing cellular damage accumulation prevention of age-related decline (including Alpha ketoglutarate, Quercetin, Glucosamine, Carnosine, Pterostilbene, Astaxanthin, and Curcumin)
Placebo/control
In the control cohort, participants will take Vitamin C (1x/day) and Vitamin E (1x/week) as placebo agents.
B12
In both intervention groups, participants will take vitamin B12 once daily.
Intervention: Guided Meditation Program
Intervention group participants will follow a daily, app-based meditation program for 20 minutes a day.
Control: Podcast Listening Activity
Control participants will listen to a neutral podcast for 20 minutes a day designed to control for time and attention.
Control: Standard Exercise Regimen
Control group participants will engage in a standard exercise regimen (150 minutes of aerobic activity such as walking per week).
Intervention: Structured Exercise Program
Intervention group participants will follow a structured daily exercise program including resistance training and a recommendation for 150 minutes of aerobic activity (e.g., walking) per week.
Locations (1)
AgelessRx
Ann Arbor, Michigan, United States