Clinical Research Directory

Inclusion Criteria: * Community-dwelling women and men (sex) aged between 55 and 70 years * low daily exercise (i.e. \<4000 steps/day on average in the last month, self-assessment) * low fruit and vegetable intake (\< 3 per day) * at risk for accelerated functional and biological aging based on the following criteria: * overweight (BMI between 25.0 and 29.9) * at least one of the following lab values or at least borderline blood pressure within the mentioned range: * HbA1c 5.7 - 6.4% (pre-diabetes) * LDL 3.4 - 4.1 mmol L-¹ or TG \> 1.7 mmol L-¹ (atherogenesis) * hs-CRP 2 - 3 mg L-¹ (low-grade inflammation) * increase in BP or borderline BP (SBP 130 - 139 / DBP 85 - 89 mmHg) * availability of a smartphone and agrees that it can be used to connect the activity tracker to the internet and consent that data from the activity tracker will be uploaded and analyzed * Ability to communicate, read and write in German * Dietary tolerability of a Mediterranean diet (e.g. vegetables, olive oil, white meat, fish, plant-based proteins) * Ability to swallow supplement capsules Exclusion Criteria: * current smoking or vaping (smoker = More than 100 cigarettes or vapes in a life-time OR quitted less than 15 years ago and smoked more than 8 pack-years OR quitted less than 10 years ago and smoked max. 8 pack-years) * current supplementation with vitamin D and/or omega-3 and/or Fruitflow® and/or Centrum Silver® Adults 50+ multivitamin and/or taking any other multi-vitamin preparate and not willing to forgo during the trial duration * prior (ever used for more than 3 months) or current intake/application of metformin and/or GLP-1 and/or SGLT-2-inhibitor. * Current or recent (previous 12 months) participation in another clinical trial, or plans of such participation during participation in this trial * Presence of the following diagnosed health conditions in the last 4 years: * cancer (except non-melanoma skin cancer) * myocardial infarction, stroke, transient ischemic attack, angina pectoris, or coronary artery intervention * renal impairment and/or liver disease * relevant/severe impairment in mobility that leads to an inability to participate in the exercise component * major visual or hearing impairment * other serious illness that would preclude participation in the intervention components * Living together with another study participant