Clinical Research Directory

Inclusion Criteria: * Clear source: This project is supported by the Affiliated Dental Hospital of Zhejiang University School of Medicine; * Make sure to collect all patients' age, gender, and basic test information. The age range is 6-18 years old, and there is no restriction on gender; ③ The subjects and/or their families are able to understand the purpose of the trial, are willing to cooperate, and voluntarily or/and with the consent of their families, agree to participate in the trial and sign the informed consent form. Exclusion Criteria: * Magnetic resonance imaging detected significant abnormalities in brain structure; * Severe sensory organ damage (blindness, hearing loss); ③ Having organic gastrointestinal problems; * Taking antibiotics or immunosuppressive drugs within one month; * Autism and other conditions that have been clearly linked to genetics; ⑥ Obvious abnormalities in oral mucosa; ⑦ Wearing various orthodontic appliances and accessories.