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Aprepitant to Improve Same Day Discharge for TKA
Sponsor: Endeavor Health
Summary
The purpose of this research is to study whether adding an FDA approved medication called aprepitant (a medication given to patients like you to reduce or eliminate nausea and vomiting) to the usual treatment to prevent nausea and vomiting given to patients during knee replacement surgery helps more patients go home on the same day of surgery (before midnight) by eliminating nausea and vomiting.
Official title: Preoperative Aprepitant to Improve Same-Day Discharge After Total Knee Arthroplasty: A Randomized Double-Blind Placebo-Controlled Trial
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
350
Start Date
2026-07
Completion Date
2027-08
Last Updated
2026-06-10
Healthy Volunteers
No
Conditions
Interventions
Aprepitant Injection
32mg aprepitant will be administered intravenously preoperatively during single sided total knee arthroscopy
Ondansetron (Zofran)
4 mg IV ondansetron will be given at surgical closure during total knee arthroscopy
Dexamethasone
4 mg IV dexamethasone will be given after induction of MAC sedation anesthesia during total knee arthroscopy
Placebo
Patients will receive 32 mg of intravenous (IV) placebo preoperatively for a total knee arthroscopy
Locations (1)
Endeavor Health Skokie Hospital
Skokie, Illinois, United States