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COMPLETED
NCT07768657
NA

Improvement in Hepatic Function Through Sumac (Rhus Coriaria L.) Supplement Along With a Calorie-restricted Diet for the Management of Grade-I Obese Non-alcoholic Fatty Liver Disease Patients

Sponsor: University of Lahore

View on ClinicalTrials.gov

Summary

This randomized controlled trial aims to evaluate the effects of Rhus coriaria L. (Sumac) supplementation combined with a calorie-restricted diet on hepatic function and metabolic health in grade-I obese patients with non-alcoholic fatty liver disease (NAFLD). A total of 102 participants aged 30-60 years with confirmed NAFLD will be randomly assigned to one of three groups: placebo, 1.5 g/day Sumac supplementation, or 3.0 g/day Sumac supplementation for 12 weeks. Outcomes will include changes in liver function tests (ALT, AST, and ALP), anthropometric measurements, glycemic control, insulin resistance, lipid profile, and inflammatory biomarkers. The study aims to determine whether Sumac supplementation provides additional benefits beyond calorie restriction alone in improving hepatic health and metabolic risk factors associated with NAFLD.

Official title: Hepatic Function Through Sumac (Rhus Coriaria L.) Supplement Along With a Calorie-restricted Diet

Key Details

Gender

All

Age Range

30 Years - 60 Years

Study Type

INTERVENTIONAL

Enrollment

102

Start Date

2025-06-05

Completion Date

2025-09-16

Last Updated

2026-08-17

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

T1 SUMAC SUPPLEMENT

T₁ received 1.5 g/day of Sumac supplementation with a calorie-restricted diet (1250-1300 kcal/day)

DIETARY_SUPPLEMENT

T2 SUMAC SUPPLEMENT

T₂ received 3.0 g/day of Sumac supplementation with the same calorie-restricted diet for 12 weeks

DIETARY_SUPPLEMENT

Placebo (Starch Capsule)

One starch capsule administered daily for 12 weeks.

Locations (1)

Sana Noreen

Lahore, Punjab Province, Pakistan