Clinical Research Directory

Inclusion Criteria: 1. Chinese female subjects aged 35 to 60 years (inclusive) in good general health based on subjective self-report and investigator assessment. 2. Fitzpatrick skin type II, III, or IV. 3. Self-reported dry skin type. 4. Meets specified skin criteria assessed by investigator: Crow's feet wrinkle grade between 3 and 5 (inclusive), with priority given to subjects with a side-to-side difference ≤ 0.5 in grade. 5. Facial trans-epidermal water loss (TEWL) ≥ 6 g/m²·h as measured by Vapometer. 6. Facial stratum corneum hydration level between 20 and 45 (inclusive) as measured by Corneometer. 7. Willing to avoid excessive sun exposure throughout the study period. 8. Females of childbearing potential (FCBP) must agree to use highly effective contraception methods or remain abstinent from 1 month prior to study start through study completion; or postmenopausal females. 9. FCBP must have a negative urine pregnancy test at screening. 10. Willing to undergo tape-stripping procedures for stratum corneum sampling. 11. No other dermatological conditions deemed unsuitable for participation (e.g., facial tattoos, scars). 12. Willing to sign Informed Consent Form (ICF) and Image Authorization Form. 13. Able and willing to comply with all study procedures and visit schedules. Exclusion Criteria: 1. Current pregnancy, breastfeeding, or planning to become pregnant. 2. Current smokers or history of smoking within the last 6 months (including e-cigarettes/nicotine products). 3. History of facial cosmetic procedures (fillers, lasers, implants, Botox, etc.). 4. Active systemic or localized skin diseases (acne, eczema, psoriasis, atopic dermatitis). 5. Known allergies to cosmetics, personal care products, or their ingredients. 6. Excessive UV exposure or frequent sauna/water sports usage. 7. Use of antihistamines, antibiotics, corticosteroids, or NSAIDs within relevant washout periods. 8. Participation in any other clinical trial within the past 30 days. 9. Planned surgical or invasive procedures during the study period. 10. Individuals deprived of liberty by judicial or administrative order. 11. Subjects who cannot be reached by telephone in case of an emergency. 12. Any other condition that, in the investigator's opinion, makes the subject unsuitable for participation.