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Sex Hormones and Aging
Sponsor: University of Michigan
Summary
This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training. Age-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.
Official title: Hormone-Related Mechanisms of Neuromuscular Aging and Exercise Adaptation
Key Details
Gender
FEMALE
Age Range
50 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2026-08-20
Completion Date
2031-08
Last Updated
2026-09-30
Healthy Volunteers
Yes
Conditions
Interventions
HRT: High-Resistance Strength Training
Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.
Control: High-Resistance Strength Training
Each participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.
Locations (1)
University of Michigan
Ann Arbor, Michigan, United States