Clinical Research Directory

Inclusion Criteria: * Male and female participants aged 60 to 75 years. * Diagnosed with frailty syndrome meeting the following criteria: 1. Clinical Frailty Scale (CFS) score between 3 (Managing Well) and 6 (Moderately Frail). 2. Meeting at least 3 out of 5 modified Fried criteria: (a) Unintentional weight loss, (b) Decreased handgrip strength, (c) Slow walking speed, (d) Low physical activity, (e) Self-reported persistent exhaustion. * Willing and able to provide written informed consent to participate in the study. Exclusion Criteria: * Mini-Mental State Examination (MMSE) score \<= 20. * Currently on an organ transplant waiting list. * Significant abnormal laboratory values: hemoglobin \< 10 g/dL, white blood cell count \< 3,000/mm³, platelet count \< 120,000/mm³, alkaline phosphatase \> 3x ULN, total bilirubin \> 1.5 mg/dL. * Major comorbidities: NYHA class III-IV heart failure, GOLD group C/D chronic obstructive pulmonary disease (COPD), stroke or history of stroke, end-stage renal disease, severe liver disease or active hepatitis (Child-Pugh B/C, acute hepatitis, active chronic hepatitis, or unexplained AST/ALT \> 3x ULN), uncontrolled type 2 diabetes mellitus with HbA1c \> 8.5%, HIV infection, active acute infection requiring systemic antibiotics, coagulation disorders, or grade 4 knee osteoarthritis. * Active malignancy within the past 5 years. * Life expectancy of less than 1 year. * Symptomatic urinary tract stones requiring intervention. * Current use of H1 or H2 receptor antagonists. * History of autoimmune diseases requiring immunosuppressive or biologic therapy. * Severe malnutrition or limb amputation. * Chronic gastrointestinal diseases causing malabsorption syndrome.