Clinical Research Directory

Differences In Microbiota Profiles Of Pediatric Appendicitis Cases

Sponsor: Istanbul University

Summary

The microbial profile varies between simple appendicitis (SA) and complicated appendicitis (CA) cases. An appendectomy has been noted to temporarily diminish gut bacterial diversity. Changes in the microbial profile associated with appendicitis are known to significantly influence the development of acute appendicitis (AA). Therefore accurately distinguishing between SA and CA cases is essential for selecting suitable treatment approaches. The aim of this clinical study is to determine whether the gut bacterial profile plays a role in cases of simple and severe appendicitis in pediatric patients. Healthy volunteers will also be included in the study for the purpose of comparing results. The key questions the researchers aim to answer are: Are there differences in the biochemical values of participants with simple versus severe appendicitis? Are there differences in the gut bacteria present in cases of simple versus severe appendicitis? There are no specific procedures or requirements for the participants or healthy volunteers to follow. There will be no changes to their treatment or medical care.

Official title: Differences In Microbiota Profiles Of Simple And Complicated Pediatric Appendicitis Cases

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