Clinical Research Directory

Arch-Clamping Technique Under Mild Hypothermia in Treating With Acute Type A Aortic Dissection

The study is a multicenter, three-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 306 participants diagnosed with acute type A aortic dissection (ATAAD) from 7 hospitals in China. All patients receive total arch replacement (TAR) combined with frozen elephant trunk (FET) implantation and are randomized to Group 1 (arch-clamping technique under mild hypothermia), Group 2 (arch-clamping technique under moderate hypothermia) and Group 3 (Sun's procedure using bilateral antegrade cerebral perfusion) in the ratio of 1:1:1. After a 1-year follow-up, the validity and safety of the mild hypothermic arch-clamping technique for ATAAD was evaluated via the incidence of major adverse events including death, renal replacement therapy, stroke, and paraplegia, as well as times of circulatory arrest, cardiopulmonary bypass, and mechanical ventilation, and length of ICU stay.

A Prediction Model of Prolonged Mechanical Ventilation Following Acute Type A Aortic Dissection Surgery

The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery. The main questions it aims to answer are: 1. To validate the predictive performance of the model for PMV after ATAAD surgery 2. To assess the proportion of PMV among patients undergoing ATAAD surgery 3. To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery