Clinical Research Directory

TCP-600 Supplementation and Performance Response in Professional Football Players

This study will examine whether a 14-day supplementation protocol containing taurine, caffeine, and phosphatidylserine can help professional male football players maintain physical performance, cognitive function, recovery-related readiness, and selected football-specific perceptual-cognitive performance. Participants will be randomly assigned to receive either placebo or a phosphatidylserine-containing multi-ingredient supplement. Before and after the supplementation period, players will complete non-invasive assessments such as sprint testing, reaction-time testing, heart rate variability monitoring, wellness/readiness questionnaires, mental-fatigue measures, and selected football-specific perceptual-cognitive tasks where available. The study is designed as an external validation and extension of responder profiles derived from previous randomized controlled trials. Data from previous trials and this validation cohort will be used to examine whether baseline physical, cognitive, autonomic, fatigue-related, recovery-related, or perceptual-cognitive characteristics can predict which players are most likely to benefit from phosphatidylserine-containing multi-ingredient supplementation.

Effects of Short Physical Activity Breaks on Thinking Skills After University Lectures in Undergraduate Students

The goal of this randomized crossover study is to evaluate whether brief Physical Activity Breaks (PABs), implemented immediately after lecture-based academic activity, can improve attentional processing and executive functioning in undergraduate university students. The main questions it aims to answer are: Do OPAB or PABEx improve attentional and executive performance compared to a no-break control condition (NPAB)? Does PABEx provide superior cognitive benefits compared to OPAB? Researchers will compare: OPAB (a standardized 10-minute outdoor walking protocol) PABEx (a 10-minute exergame-based break using Fruit Ninja Kinect) to see if these interventions improve cognitive performance compared to NPAB (supervised passive seated rest), and whether significant differences in cognitive outcomes emerge between OPAB and PABEx. Participants will: Complete cognitive assessments (Trail Making Test A-B and Stroop Color-Word Test) immediately after each condition. Be randomly assigned, in counterbalanced order, to all three conditions across three consecutive weeks separated by a 7-day washout interval. Engage in a 10-minute structured break (OPAB or PABEx) or passive rest (NPAB) following two consecutive hours of seated university lectures, including: Warm-up (2 minutes): low-intensity dynamic movements. Main session (6 minutes): light-to-moderate outdoor walking (OPAB) or Fruit Ninja Kinect exergaming (PABEx). Cool-down (2 minutes): relaxation and gentle stretching exercises. This study will provide insights into the efficacy of brief active breaks as a pragmatic strategy to enhance cognitive efficiency in university students during academically demanding periods.

Functional and Performance Determinants in Climbers: Examining the Role of Mobility, Stability, and Fatigue Across Proficiency Levels

The primary objective is to understand how motor skills and fatigue affect climbing performance in indoor and outdoor climbers, also comparing elite and amateur climbers. Aims: * Assess differences in selected joint range of motion, isometric strength, and dynamic stability between elite and intermediate climbers. * Evaluate the impact of the fatigue protocol on functional performance and cognitive outcomes across climbers of varying skill levels (intermediate vs. advanced). * Examine the impact of general joint hypermobility, as indicated by Beighton Scores, on functional climbing performance. * Association between cognitive factors (e.g., attention, memory) and motor skills. Research questions: * Do elite climbers have better joint mobility and balance than amateur climbers? * How does fatigue affect performance and reaction time and cognitive function? * Does having flexible joints (joint hypermobility) make climbers better athletes * What are the performance differences between indoor and outdoor climbers? This study will help identify key skills and physical traits that improve climbing performance. It will also explore how fatigue and flexibility impact safety and performance in different climbing environments.