Clinical Research Directory

Innovative Web-based Service Platform Called Adult Wellbeing CheckUp (AWC) to Assess Older Adults Wellbeing, Obtain Evidence-based Recommendations, and Receive Support to Take Action.

The goal of this clinical trial is to learn whether a web-based program called the Adult Wellbeing CheckUp (AWC) can help older adults improve their wellbeing and take actions to support healthy aging. The study will include adults aged 60 years and older, including both older adults and people who care for someone living with Alzheimer's disease or related dementias. The main questions this study aims to answer are: 1. Does using the Adult Wellbeing CheckUp increase participants' ability to manage their health and wellbeing, measured by the Patient Activation Measure (PAM-13)? 2. Do participants who use the Adult Wellbeing CheckUp take more actions to improve their wellbeing compared with those who do not use the program? Researchers will compare participants who use the AWC platform with participants who receive general healthy aging information to see whether the AWC program leads to greater improvements in wellbeing and health engagement. The AWC platform is an online tool that helps older adults review their wellbeing across several areas of life, such as physical health, mental health, social connections, and daily habits. After completing an online assessment, the platform provides personal action plans and specific recommendations to help participants improve areas where their wellbeing scores are low. About 496 participants aged 60 and older will take part in this study. This group will include both older adults and care partners for people living with Alzheimer's disease or related dementias. Participants will take part in the study for about 24 weeks (6 months). Participants will be randomly assigned (by chance) to one of two groups: 1. Intervention group: Participants will create an account and use the Adult Wellbeing CheckUp platform for 24 weeks. They will complete a wellbeing assessment and receive personal action plans and specific recommendations. They will also receive weekly encouragement messages and personalized check-ins by email or text. 2. Comparison group: Participants will complete the same baseline assessment but will not have access to the AWC platform during the study. Instead, they will receive weekly general healthy aging information by email. All participants will complete surveys at the start of the study, at 12 weeks, and at 24 weeks. These surveys will measure health engagement, wellbeing, and actions taken to improve wellbeing. After the study ends, participants in the comparison group may be offered access to the platform in a future time. Researchers will use the results of this study to learn whether the Adult Wellbeing CheckUp can help older adults take meaningful steps to improve their health and wellbeing.

NSS Grocery Store Brazil

The purpose of this study is to assess the impact of non-sugar sweeteners (NSS) front-of-package labels (FOPL) on Brazilian parents' food and beverage selections for their children. The study includes three arms: 1. no NSS FOPL control group, 2. a group exposed to a NSS FOPL modeled after the Mexican warning label for NSS, and 3. a group exposed to a NSS FOPL using the magnifying glass symbol currently implemented in Brazil for nutrients of public health concern. Participants will be instructed to select products for their child, including one yogurt, three beverages (for breakfast, lunch, and dinner), one granola, and one cereal bar.

"Bupe by the Book": A Tele-Buprenorphine Clinical Trial in Public Libraries With Unstably Housed Persons With Opioid Use Disorder

Public libraries nationwide are facing an on-premise opioid overdose crisis. Many persons with opioid use disorder (OUD) remained unhoused and profoundly hard to reach. This study innovatively develops and tests a telemedicine intervention delivered through public libraries to increase unstably housed individuals' access to bupe treatment that would prevent overdoses from occurring in the first place. The investigators will conduct a 12-week pilot 2-arm randomized controlled trial (RCT) (n=40). Research staff will recruit library patrons and randomize them to weekly telehealth at the library or in-person clinic control arms across two participating libraries in San Diego.

Internet Delivered Therapy for Social Anxiety in Adults

The goal of this clinical trial is to learn if an internet-delivered CBT protocol for social anxiety in adults (PORTiSOFIE) is effective in Portugal. It will also learn about the impact that PORTiSOFIE may have on relationship dimensions of these individuals. The main questions it aims to answer are: Does PORTiSOFIE is effective? What impact PORTiSOFIE has in relationship dimensions? Participants will: Be assigned to experimental group and receive intervention briefly after screening is complete; Or control group and only receive intervention after the experimental group finishes.

Effects of an Augmented Reality Exercise Program in Older Adults

This research aims to examine the effects of an augmented reality (AR) exercise program on physical fitness (cardiorespiratory capacity, strength, balance, agility, and flexibility) and cognitive function (reaction time, decision-making, and memory).