Clinical Research Directory

Bulk-Fill Composite Restorations: Clinical Evaluation

This randomized controlled clinical study aims to evaluate the clinical performance of five different bulk-fill composite materials representing distinct technological approaches according to the World Dental Federation (FDI) criteria. The materials include a thermoviscous bulk-fill composite applied with preheating, a sonic-activated bulk-fill composite, a flowable bulk-fill composite, an ORMOCER-based bulk-fill composite, and a conventional bulk-fill composite. Restorations will be clinically assessed at baseline, 1 month, 6 months, and 12 months for esthetic, functional, and biological outcomes.

Clinical Success of Single-Color Universal Resin Composites

According to FDI criteria, the success of 4 different universal resin composites was targeted. In our study, a total of 180 teeth will be restored in class 2 cavities with 5 different composite resins in 5 groups.

One-Step Universal Adhesives: A 3-year Clinical Trial in Class II Composite Restorations

to evaluate and compare the clinical performance and periodontal responses of four commercially available one-step universal adhesives with different formulations in Class II composite restorations over a three-year period.

Clinical Performance of Novel Alkasite Restorative Material "Cention Forte" in Class II Restorations

Background \& Rationale: Self-adhesive materials eliminate the need for adhesive protocols, offering advantages for direct restorations. The bulk-fill technique simplifies application by allowing a single-layer restoration. Glass ionomer cements (GICs) provide benefits such as fluoride release, remineralization, and moisture tolerance but have limitations, including poor aesthetics and low mechanical strength. To overcome these, hybrid materials combining GIC properties with composite durability have emerged. Cention Forte, a capsulated alkasite restorative material, offers high flexural strength (\>100 MPa), bioactivity, and ease of application. The manufacturer claims it is an ideal posterior restorative, potentially replacing composite resins and amalgam. Given that composite restorations fail more frequently in patients with isolation difficulties, limited mouth opening, or parafunctional habits, alternative materials are needed. This study evaluates Cention Forte as an alternative to conventional composites. Objective: To compare the clinical performance of Cention Forte with a universal composite resin (G-aenial Achord, GC) in Class II restorations over 18 months using FDI (World Dental Federation) criteria. Hypothesis: H₀: No significant difference between Cention Forte and composite resin after 18 months based on FDI criteria. Primary Endpoint: At least 90% of restorations remain intact at 18 months with no significant differences in clinical performance. Study Design: A randomized, controlled, single-blind clinical trial with 30 healthy volunteers (18-35 years old), each receiving two restorations (one with Cention Forte, one with G-aenial Achord). Bite-wing radiographs will be taken before and after treatment, and at 6 , 12 and 18 months. Eligibility Criteria: Inclusion: * 18-35 years old, systemically healthy. * Brushing twice daily, at least 20 teeth in occlusion. * At least two interproximal Class II lesions. * Signed informed consent. Exclusion: * Pregnancy/lactation. * Advanced periodontal disease, bruxism, malocclusion. * Allergy to resin materials or local anesthesia. * Endodontically treated teeth or pulp capping cases. Restorative Procedure: Study Group (Cention Forte): Self-etch primer applied, followed by Cention Forte placement and light-curing. Control Group (G-aenial Achord, GC): Selective enamel etching with 37% phosphoric acid, followed by G-Premio Universal Adhesive and incremental layering with light-curing. Clinical Evaluations (FDI Criteria): Aesthetic properties: Color match, marginal discoloration, anatomical form. Functional properties: Fracture resistance, marginal adaptation, occlusal wear, proximal contact. Biological properties: Postoperative sensitivity, secondary caries, periodontal response. Scoring: 1 (excellent) to 5 (unacceptable). Statistical Analysis: Chi-square/Fisher's Exact Test: Compare clinical performance. Wilcoxon signed-rank test: Evaluate performance over time. Kaplan-Meier survival analysis: Assess restoration longevity. p \< 0.05 considered statistically significant. Ethical Considerations \& Data Management: Ethical approval from Hacettepe University Clinical Research Ethics Committee. Registration on ClinicalTrials.gov. Data secured and encrypted, accessible only to authorized personnel. Expected Impact: This study will assess whether Cention Forte is a viable alternative to composites, particularly for challenging clinical cases where isolation and durability are concerns.