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Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation

Tundra lists 1 Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation clinical trial. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.

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NCT05218005

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia

ACCURATE will test the hypothesis that opportunistic genetic testing for Familial Hypercholesterolemia (FH) in patients admitted to hospital with an acute coronary syndrome will increase the diagnosis of FH and will impact patient care and outcomes. The study will recruit patients admitted to hospital with an acute coronary syndrome, and research-based genetic testing will be conducted for known FH-causing genetic variants. The results will be returned to the patients' treating physicians. The primary endpoint will be the number of patients with a new diagnosis of definite FH. The secondary endpoints will be the proportion of patients who undergo intensification of lipid-lowering therapy, the lowest LDL cholesterol level achieved, and the proportion of patients reaching guideline recommended lipid targets in the 15 months after the index acute coronary syndrome.

Gender: All

Ages: 18 Years - 60 Years

Updated: 2026-05-01

1 state

Familial Hypercholesterolemia

Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B

Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation