Clinical Research Directory

Validation of Serum Metabolite Differences in Patients With Gallstones and Gallbladder Cancer

We have observed that the serum levels of certain metabolites differ between Chilean patients with gallbladder cancer and those with gallstone disease. Based on these discovery results, we selected ten candidate metabolites based on the smallest p-values among metabolites exhibiting a fold-change greater than 1.5. The aim of the present study is to validate these ten differential metabolite levels in an independent cohort of Chilean patients with gallbladder cancer and gallstone disease, and to assess the transferability of these findings to other patient populations.

Validation of Differential Serum Levels for Five Minerals in South American Gallstone Patients With and Without Gallbladder Cancer

We have previously observed that serum concentrations of five minerals - aluminium, copper, sulphur, zinc, and bromine - differ between South American patients with gallbladder cancer and those with gallstones. The aim of this study is to confirm these differences using an independent set of serum samples from South American patients

Validation of the Association Between the Abundance of Three Bacterial Genera in Stool Samples and the Risk of Gallbladder Cancer in South American Patients With Gallstones

In our previous work, we found three types of bacteria in stool samples from South American patients with gallstones linked to a higher risk of gallbladder cancer. The aim of the present study is to confirm these associations using a separate set of South American stool samples.