Clinical Research Directory

Probiotic Intervention in Constipation

To evaluate the effects of probiotic intervention on gastrointestinal function in patients with constipation after 4 weeks of treatment, and to explore its potential effects on immune status and bone metabolism.

Impact of Weizmannia (Bacillus) Coagulans JBI-YZ6.3 on Gut Health and Fecal Microbiome Changes

This study will evaluate the effects of supplementation with Weizmannia (Bacillus) coagulans JBI-YZ6.3 on gastrointestinal health in healthy, physically active adults. The primary objective is to determine whether daily intake of this probiotic strain improves symptoms of constipation and related gastrointestinal function compared with placebo. Approximately 30 healthy men and women aged 18 to 50 years will be enrolled in a randomized, double-blind, placebo-controlled, crossover trial. Participants will complete two 4-week supplementation periods, one with Weizmannia (Bacillus) coagulans JBI-YZ6.3 and one with placebo, separated by a 4-week washout period. The total duration of participation will be approximately 13 to 14 weeks, including screening and testing visits. Gastrointestinal symptoms will be assessed at baseline and after each supplementation period using validated questionnaires, with particular focus on the constipation domain of the Gastrointestinal Symptom Rating Scale (GSRS). Secondary outcomes will include additional gastrointestinal symptom domains and markers of perceived gut comfort and function. This study is designed to determine whether supplementation with Weizmannia (Bacillus) coagulans JBI-YZ6.3 produces clinically meaningful improvements in gastrointestinal symptoms in physically active adults compared with placebo.

The Effect of Heat Application and Abdominal Massage on the Gastrointestinal System and Mental Well-being of Patients With Hip Fractures

This randomised controlled trial was designed to determine the effect of early-stage heat application and abdominal massage on patients' gastrointestinal function and mental well-being following hip fracture surgery. The study's hypotheses are as follows: H0: Heat application and abdominal massage administered in the early postoperative period have no effect on gastrointestinal function or mental well-being. H1: Heat application in the early postoperative period affects gastrointestinal function and mental well-being. H2: Abdominal massage administered in the early postoperative period has an effect on gastrointestinal function and mental well-being. The Patient Information Form, Gastrointestinal Symptom Rating Scale (GSRS) and Warwick-Edinburgh Mental Well-being Scale will be administered. Starting from the morning of the first day after surgery, patients will receive abdominal massage and heat application twice daily, in the morning and evening, for three days. The warm compress and abdominal massage will be performed consecutively. The total application time will be 30 minutes, consisting of 15 minutes of warm compress and 15 minutes of abdominal massage. Abdominal massage will be performed on patients in the experimental group using the 'abdominal massage application guidelines'. Abdominal massage involves techniques such as effleurage (stroking and spreading), petrissage (kneading) and vibration. After each application of massage, the patient's bowel sounds and movements will be listened to using a stethoscope. Before applying heat and performing the abdominal massage, care will be taken to ensure that the patient does not need to urinate, and that the room is quiet and at a suitable temperature. Patients in the experimental group will not be given laxatives, suppositories or enemas for three days; only heat application and massage will be performed during this period. During this period, researchers will assess the defecation of patients using the Bristol Stool Scale. At the end of the three-day follow-up period, patients will be asked to complete the Bristol Stool Scale, the Gastrointestinal Symptom Rating Scale and the Warwick-Edinburgh Mental Well-being Scale.

Probiotics and Non-Organic Gastrointestinal Improvement

To verify the improvement of gastrointestinal function in patients with non-organic gastrointestinal dysfunction after 4 weeks of intervention with compound probiotics.

Exercise Improves Gastrointestinal Function in Peritoneal Dialysis Patients

This study will investigate the impact of exercise on gastrointestinal function in peritoneal dialysis patients.