Clinical Research Directory

Brain Health on College Campuses

Center for BrainHealth is beginning a one-year pilot with local college campuses investigating the impact of (i) brain health assessment and training tools delivered through the online BrainHealth Platform and (ii) in-person educational brain health workshops delivered to college students and faculty/staff, with the overarching goal to better understand how to promote brain-healthier campuses (i.e., reflecting generally positive function across cognitive, social, emotional, and lifestyle domains). This initial study is intended to be a one-year pilot, with findings informing feasibility and efficacy as well as future, more extended and expanded study informing translation to other colleges/universities.

LiPO Teen (the Lifestyle in Pregnancy and Offspring Teenagers

The study is a follow-up of a Randomized Controlled Trial (RCT) performed in 2007-10 - the "Lifestyle in Pregnancy" LiP study. The LiP study included 360 pregnant women with BMI ≥30 kg/m2 from Odense University Hospital and Aarhus University Hospital. The women were randomized to intervention with low-calorie diet and physical activity from gestational age 10-14 in pregnancy and until delivery - or to a standard care control group. The objective of the LiPO-Teen project is to perform a clinical follow-up study of the eligible 301 mothers who completed the trial until delivery with a liveborn child, and their 14 year-old offspring. The overall ambition is to understand whether lifestyle intervention in pregnancy prevents obesity and its complications across generations, with a specific focus on modifiable factors.

Protocol for a Natural-Based Intervention to Promote Quality of Life and Healthy Habits on Children and Adolescents.

In current society, physical activity practices show a decreasing trend, together with a low perception of life quality. In addition, urban overcrowding has led to disconnection from the natural environment, causing the benefits that this context offers to be lost, especially for children and adolescents. Physical literacy is an approach to physical activity that encompasses more than just individual physical skills. It emphasises the importance of performing physical activity on a regular basis as part of daily life, encompassing bodily expression and understanding, as well as self-confidence and motivation, making it a factor that contributes to quality of life. Although research shows a correlation between physical literacy and life satisfaction, there is no research on other variables, such as the impact of green spaces in this correlation. This study aimed to present the rationale and methods of a randomized controlled trial in green spaces for children and adolescents aged 8 to 18 to evaluate the efficacy of a nature-based intervention designed to promote healthy habits through physical literacy and quality of life through life satisfaction. The statistical techniques applied will include a comprehensive method encompassing sociodemographic information, physical activity levels, perceptions of physical literacy, and life satisfaction. The camp shifts were randomly distributed, with half in the control group and the other half in the experimental group . Two measures of physical literacy and life satisfaction were measured: one at the beginning of the camp and one on the day of completion. The intervention included 24 sessions of adventure activities carried out in a natural environment, and the values obtained for both variables were collected using two questionnaires validated for these age groups. This intervention is expected to improve levels of physical literacy and perceived life satisfaction by providing valuable

Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention

Due to the increasing incidence of dementia and the lack of causal treatment, non-pharmacological interventions represent an attractive and effective therapeutic strategy of neurodegenerative diseases, such as Alzheimer's disease. The aim of the study is to assess the impact of a supervised 9-month intervention with aerobic-strength training and nutritional counseling compared to cognitive training and stretching on the brain, cognitive and motor functions, metabolism, physical fitnes and plasma markers of neurodegenertion in older adults at increased risk of developing Alzheimer's disease.

Bimbingamba Zerosix Third Phase: Studying Communities

Childhood obesity is increasing in the last years especially in developed countries, and, as well as adult obesity, is related to the development of pathologies. Unfortunately, the restoration of a normal weight condition, if the ponderal excess rose in the first years of life, seems very difficult. Despite the importance of this issue, there is a paucity of evidence demonstrating effective interventions in reducing weight over time. The observation that in developed countries childhood obesity appears with evident social and geographical gradients justifies the implementation of inter-sectoral interventions of primary prevention, to be declined at the contextual level: family and community. Nowadays, there are numerous interventions for the promotion of lifestyle in pediatric age, in particular, those aimed at primary school and adolescence. On the other hand, few interventions were directed at the 0-7 age group. Therefore, this community intervention trial involved the pediatric population (aged 0-7 years) and their families, and it is aimed at the prevention of obesity and the restoring normal weight through community interventions aimed at improving lifestyles and with them the bio-metric parameters, health and well-being outcomes and soft skills in the population aged 0-7 years. The target population is children aged 0-7 years resident in the two municipalities (Mondovì and Savigliano), respectively selected as Intervention and Control Common. Totally, to conduct this study 2000 children, of both sex, will be enrolled (near 1000 for each of the two Municipalities).

Health-Enhancing Adapted Physical Activity Program at "Mon Stade"

Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies. Nevertheless, few studies have evaluated adherence to an initial health-adapted PA (APA) program, and persistence of active behavior over the time in individuals with a chronic disease. The aim of the study is to determine the brakes and levers associated with motivation and long-term compliance. In addition, the investigators aim to evaluate the cost-effectiveness of such program in term of care consumption. Finally, the investigators complete their interest for APA prescription from practitioners agreeing to enroll their patients in the present study. Method: The investigators perform a prospective monocentric cohort, of 2024 patients affected of a chronic disease or long-term illness (LTI), enrolled from 2021 to 2024 (4 years, 506 per year), for a 16-week APA program, and followed 5 years with an annual fitness and habits of life and care consumption evaluation.