Clinical Research Directory

Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail Psoriasis

The goal of this clinical trial is to compare methotrexate injections with triamcinolone acetonide injections for treating nail psoriasis. Nail psoriasis can cause nail pitting, discoloration, thickening, and separation of the nail from the skin underneath. The study will also compare the safety of these treatments. The main questions it aims to answer are: * Which treatment produces greater improvement in nail psoriasis? * What side effects do participants experience with each treatment? Researchers will compare methotrexate with triamcinolone acetonide. Both medications will be injected intralesionally into the affected nail area. Participants will: * Receive intralesional injections according to the study treatment plan. * Attend clinic visits to assess changes in their affected nails and check for side effects. * Report any pain, discomfort, or other medical problems experienced during the study.

An Open Label Trial to Evaluate Efficacy and Safety of Roflumilast 0.3% Cream for Chronic Plaque and Nail Psoriasis

This is an open label trial in subjects ≥12 years of age and older with chronic plaque psoriasis and moderate to severe nail psoriasis. Eligible participants will apply roflumilast 0.3% cream daily for 24 weeks to affected nails daily for the entire study duration and to psoriasis plaques daily until clear.

Topical Use of 2% Tofacitinib for Nail Psoriasis: an Exploratory Clinical Study

To evaluate the efficacy and safety of topical 2% tofacitinib nail lacquer in nail psoriasis, using the NAPSI and DLQI scales before and after 26 weeks of treatment.

Local Methotrexate Injections for the Treatment of Nail Psoriasis

The investigators hope to learn the efficacy of methotrexate injections for treatment of nail psoriasis.

Study to Assess Efficacy, Safety and Tolerability of a Nail Patch in Patients With Nail Fragility, Mychosis, Psoriasis

A randomized, double blind, placebo-controlled, unicenter, parallel group study to assess the efficacy, safety and tolerability of a multi-funtion toe nail patch in patients affected by nail fragility, nail mychosis and psoriasis 72 patients in 6 subgroups Treatment duration 3 months + 1 month follow-up

Real-World Study of Xeligekimab for Moderate to Severe Plaque Psoriasis(XP-Real)

Xeligekimab Injection was approved in China on August 20, 2024, for treating adults with moderate to severe plaque psoriasis who are candidates for systemic treatment or phototherapy. Despite the promising efficacy and safety shown in the phase III clinical trial, real-world data is needed to further support clinical decisions for this patient group. This study aims to evaluate the effectiveness and safety of xeligekimab in real-world clinical settings for adults with moderate to severe plaque psoriasis.