Clinical Research Directory

Indocyanine Green Fluorescence in Endoscopic Resection of Non-Functioning Pituitary Adenomas

The goal of this study was to determine whether ICG improves outcomes in surgery for non-functioning macroadenomas. The main questions it aimed to answer were: Was gross total resection more frequent? Did ICG use lead to fewer intraoperative and postoperative complications? The investigators compared the ICG group with the control group to determine whether there were differences in outcomes between the groups. Participants received ICG intraoperatively if they had been randomly assigned to the ICG group.

Effect of Dexmedetomidine on Quality of Recovery in Non-functioning Pituitary Adenoma Patients Undergoing Endoscopic Transsphenoidal Surgery

In multiple previous studies that have explored the use of dexmedetomidine in transsphenoidal tumor resection surgery, dexmedetomidine showed many beneficial effects like reducing the requirement of analgesics and anesthetics, improving hemodynamic stability and decreasing the emergence time, extubation time and visual analog scale at emergence. Therefore, the investigators hypothesized that dexmedetomidine would decrease neuroendocrine stress response and improve the quality of postoperative recovery.

Individualized Physical Activity or Patients With Non Functioning Pituitary Adenoma

The goal of this clinical trial is to learn about physical activity's effect on health in people who have had surgery of a non-functioning pituitary adenoma. The main questions it aims to answer are: * Do physical activity increase quality of life? * Do physical activity increase general health, cardiovascular fitness, self-efficacy and muscle strength and reduce fatigue and cardiovascular risk profile? Participants will at the start of the the study, at 6 months follow up and 12 months follow up: * Fill out health surveys * Perform a cycling test, hand strength test, chair stand test and wear and accelerometer for a week * Undergo a dual energy X-ray absorptiometry to measure muscle and fat mass * Leave blood samples Researchers will compare those who are randomized to the intervention and see a physiotherapist to get an individualized and person-centred prescription of physical activity plan and those who are randomized not to be in the intervention to see if physical activity increases quality of life and general health.¨.