Clinical Research Directory

Exercise Interventions for Overweight Men With Chronic Low Back Pain

This randomized controlled trial aims to compare the effectiveness of motor control exercise, aerobic walking exercise, and muscle strengthening exercise in overweight male adults with non-specific chronic low back pain and central sensitization. A total of 156 participants will be randomly assigned to one of four groups: motor control exercise plus patient education, aerobic walking exercise plus patient education, muscle strengthening exercise plus patient education, or patient education only. The interventions will be delivered over 12 weeks. The primary outcome is conditioned pain modulation (CPM), which reflects endogenous pain inhibitory function. Secondary outcomes include pain intensity, disability, health-related quality of life, executive function, and isometric trunk muscle strength. Body weight and body mass index will also be assessed as exploratory variables. Outcomes will be evaluated at baseline, immediately after the 12-week intervention, and at 6-month follow-up.

Mindfulness-Based Therapy for Chronic Low Back Pain in Office Workers

This study evaluated whether a mindfulness-based therapy program could reduce pain severity in office workers with non-specific chronic low back pain. The study included staff members of Dokuz Eylul University aged 20 to 59 years who had low back pain for at least three months and worked at a desk for more than four hours per day. Participants were randomly assigned to either a mindfulness-based therapy group or a control group. The mindfulness-based therapy group attended online group sessions once a week for four weeks. The sessions included breathing awareness meditation, body scan meditation, self-compassion meditation, and chair yoga practices. Participants in the control group continued their usual medical care during the study period. The primary outcome of the study was pain severity, assessed using the Visual Analogue Scale. Secondary outcomes included physical activity level, disability related to low back pain, anxiety symptoms, quality of life, and mindfulness level. Participants were evaluated at baseline, Week 4 (end of intervention), Week 16 (3-month follow-up), and Week 28 (6-month follow-up).

Pelvic Floor Exercises Versus Swiss Ball Exercises in Patients With Non-Specific Chronic Low Back Pain

This randomized controlled trial aims to compare the effectiveness of pelvic floor muscle exercises and swiss ball exercises in females with non-specific chronic low back pain. The study evaluates pain intensity, disability, lumbar range of motion, and core muscle endurance following different rehabilitation protocols.

Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults

The goal of this clinical trial is to assess the clinical efficacy and safety of sodium aescinate in treating low back pain (LBP) in adult participants.

Dynamic Lumbar Strengthening Exercises Versus Pilates, Combined With Myofascial Release in Non Specific Chronic Low Back Pain

This randomized controlled trial aims to compare the effectiveness of dynamic lumbar strengthening exercises combined with myofascial release versus Pilates combined with myofascial release in individuals with non-specific chronic low back pain. Non-specific chronic low back pain is one of the most common musculoskeletal disorders affecting adults and is associated with pain, reduced spinal mobility, and functional disability. Exercise-based rehabilitation programs and manual therapy techniques are commonly used to improve functional outcomes in these patients. Dynamic lumbar strengthening exercises focus on improving spinal stability and strengthening trunk musculature, whereas Pilates exercises emphasize core muscle activation, postural control, and controlled movement patterns. Myofascial release is a manual therapy technique used to reduce fascial restrictions, improve soft tissue mobility, and decrease pain. In this randomized controlled trial, a total of 60 participants aged between 25 and 35 years with non-specific chronic low back pain lasting more than three months will be recruited from the Physiotherapy Department of the University of Lahore Teaching Hospital. Participants will be randomly allocated into two groups. Group A will receive dynamic lumbar strengthening exercises combined with myofascial release, while Group B will receive Pilates exercises combined with myofascial release. Both groups will also receive baseline therapy consisting of therapeutic massage, interferential therapy, and therapeutic ultrasound applied to the lumbosacral region. The exercise programs will be conducted for eight weeks on alternate days, with each session lasting approximately 20-25 minutes. Outcome measures will include pain intensity assessed using the Visual Analog Scale (VAS), functional disability measured using the Oswestry Disability Index (ODI), and lumbar range of motion measured using an inclinometer. Assessments will be conducted at baseline before the intervention and after completion of the 8-week intervention period. The findings of this study will help determine which exercise approach combined with myofascial release is more effective in reducing pain, improving functional disability, and enhancing spinal mobility in individuals with non-specific chronic low back pain. The results may contribute to evidence-based physiotherapy management and improve rehabilitation strategies for patients with chronic low back pain.

The Effect of Body Awareness on Pain, Disability, Sensorimotor Acuity, Psychosocial and Central Sensitization Levels in Individuals With Non-Specific Chronic Low Back Pain

This study will be conducted to examine the levels of pain, pressure pain threshold, joint position sense, sensation, functionality, pain catastrophizing, central sensitization, and body awareness in individuals with non-specific chronic low back pain, and to compare these findings with those of healthy individuals. Additionally, the study will aim to objectively investigate the relationships between lumbar self-perception (FreBAQ) and tactile acuity (TPDT), pressure pain threshold (PPT), lumbar joint position sense (LJPS), as well as psychosocial (PCS) and central sensitization (CSI) indicators in individuals with non-specific chronic low back pain. Furthermore, the study will seek to evaluate the predictive effects of lumbar self-perception on pain (VAS) and disability (RMDQ), in conjunction with objectively assessed sensory and sensorimotor measures in individuals with non-specific chronic low back pain.