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Tundra lists 2 Palatal Morphology clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT07777185
Evaluation of the Effect of Smoking on Palatal Donor Site Tissue Profile in the Success of Connective Tissue Grafts
This single-center prospective clinical study investigates how smoking affects palatal donor site tissue biology and, in turn, the success of connective tissue grafts used in root coverage surgery. A total of 24 systemically healthy patients with Cairo Type 1 (RT1) gingival recession will be enrolled: 12 smokers and 12 non-smokers. All participants will receive a coronally advanced flap combined with a subepithelial connective tissue graft (CAF + CTG) harvested from the palatal donor site. Both donor and recipient sites will be assessed at baseline and postoperatively (2 weeks, 1 month, and 3 months) using ultra-high frequency ultrasonography (UHFUS) to measure tissue thickness, echogenicity, structural integrity, and vascularization. Residual connective tissue fragments obtained during routine graft preparation will undergo histological, histochemical, and immunohistochemical analysis (including COL1A1, COL1A2, COL3A1, α-SMA, CD31, Factor XIIIa, and IL-33). Smoking status will be biochemically confirmed via salivary cotinine ELISA. Clinical outcomes (recession depth, clinical attachment level, keratinized tissue height, percentage of root coverage) and patient-reported outcome measures (PROMs) will be compared between groups. Primary Hypothesis: Smoking negatively affects palatal donor site biology, impairing the clinical and ultrasonographic healing outcomes of CAF + CTG procedures.
Gender: All
Ages: 18 Years - 65 Years
Updated: 2026-08-20
1 state
NCT07363213
Palatal Morphology, Age, and Greater Palatine Canal Anatomy on CBCT
The primary objective of this study is to quantify the relationship between palatal morphology-including vault height, angle, width, and palatal bone thickness-and the dimensions and position of the greater palatine canal (GPC) and foramen (GPF). Secondary objectives include evaluating how age and sex relate to GPC/GPF measurements, as well as describing the prevalence and anatomical variations, including shapes, of accessory (lesser) palatine canals and foramina.
Gender: All
Ages: 18 Years - 65 Years
Updated: 2026-01-27