Clinical Research Directory
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2 clinical studies listed.
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Tundra lists 2 Pulp and Periapical Tissue Disease clinical trials. Each listing includes eligibility criteria, study locations, and direct links to research sites in the Tundra directory.
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NCT07732985
Comparative Analysis of Diagnostic Accuracy and Case Difficulty Assessment of Three Large Language Models
This prospective, blinded diagnostic accuracy study aims to compare the performance of three large language models-ChatGPT (GPT-5.5 Pro), Gemini 3.1 Pro, and Claude Opus 4.7-in endodontic diagnosis and case difficulty assessment. The models will be evaluated against expert consensus as the reference standard using standardized clinical data and periapical radiographs. Diagnostic accuracy, sensitivity, specificity, and agreement with expert consensus will be assessed to determine the potential of LLMs as clinical decision-support tools in endodontics.
Gender: All
Ages: 16 Years - Any
Updated: 2026-07-29
NCT07468643
Gingival Crevicular Fluid Biomarkers and Healing After Root Canal Treatment in Asymptomatic Apical Periodontitis
This prospective observational cohort study will evaluate whether changes in gingival crevicular fluid osteoprotegerin (OPG) , RANKL/OPG ratio ,IL10,IL8and CxCL10 after primary nonsurgical root canal treatment are associated with 12-month radiographic healing in teeth with asymptomatic apical periodontitis. Participants will undergo standardized treatment and follow-up with serial GCF sampling and standardized digital periapical radiography.
Gender: All
Ages: 18 Years - 40 Years
Updated: 2026-03-12