Clinical Research Directory

Evaluating Non-Invasive Haptics During Extreme Exercise

This study aims to compare determinants of endurance performance between participants wearing an active patch with haptic vibrotactile trigger technology (VTT) versus a placebo patch without VTT among recreational to competitive runners over a 4-week training period.

Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.

The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects: * Aerobic capacity (VO₂max) * Ventilatory thresholds * Blood lactate levels * Perceived exertion This research aims to better understand how oxygen availability influences physiological adaptations to exercise. If you agree to participate, you will undergo the following: Baseline testing: * Cardiopulmonary exercise test (cycling until exhaustion) * Measurement of oxygen consumption, heart rate, and ventilatory thresholds * Blood lactate measurement (finger prick) Training intervention (3 weeks): * 3 sessions per week (total of 9 sessions) * High-intensity interval training (Tabata protocol: 8 × 20 seconds effort / 10 seconds rest) * Exercise performed on an air-resistance cycle ergometer During training, you will breathe either: * Hyperoxic air (high oxygen concentration) or * Hypoxic air (low oxygen concentration) You will be randomly assigned to one of these conditions. Post-intervention testing: • Same assessments as baseline The risks associated with this study are similar to those encountered during high-intensity exercise: * Fatigue * Muscle soreness * Shortness of breath * Temporary discomfort from finger-prick blood sampling Breathing altered oxygen concentrations (hypoxia or hyperoxia) may induce: * Mild dizziness * Increased breathing effort (hypoxia) * Sensations of ease or altered effort perception (hyperoxia) All sessions are supervised by trained personnel, and safety monitoring is ensured throughout the study You may benefit from: * Improved physical fitness * Detailed physiological assessment (VO₂max, thresholds) However, no direct health benefit is guaranteed. Your participation is entirely voluntary. * You may withdraw at any time * You do not need to provide a reason * Withdrawal will not affect your academic or professional standing All collected data will be: * Anonymized * Stored securely * Used only for research purposes Your identity will not be disclosed in any publication. Data will be handled in accordance with applicable data protection regulations (GDPR). You have the right to: * Access your data * Request correction or deletion where applicable

Test-Retest Reliability And Validation For End-Tidal Carbon Dioxide Measurement (PetCO2) During Rest And Low-Loaded Steady State Work Using A Portable Capnograph.

The goal of this observational study is to investigate exhaled carbon dioxide measuring during rest and low-loaded work using a portable device (capnograph) and standard of care apparatus during a cardiopulmonary exercise test (CPET) in healthy volunteers. The study aims to answer: How reliable is exhaled end-tidal carbon dioxide measurement for an individual over time using both standard of care apparatus and a portable device during an ergometer test? Do the measurements correlate between the portable device and standard of care apparatus? How do changes in breathing instructions and placement of sampling cannula affect the measurements from the portable device (capnograph)? How is the reliability over time of other well established values from a cardio pulmonary exercise test? Participants will be asked to perform a modified cardiopulmonary exercise test on an ergometer twice, separated in time (1-4 weeks). Measurements are sampled alternating standard of care apparatus and a portable capnograph at rest and during low-loaded work.