Clinical Research Directory

EFFICACY OF BIOMIN FLUORIDE VERSUS SODIUM FLUORIDE VARNISHES, WITH AND WITHOUT DIODE LASER ON WHITE SPOT LESIONS REMINERALIZATION IN PRIMARY TEETH.

The goal of this randomized controlled clinical trial is to assess and compare the remineralizing effect of Biomin fluoride varnish and conventional 5% sodium fluoride varnish (Duraphat), with and without adjunctive low-level diode laser irradiation, in preschool children with active white spot lesions in primary anterior teeth. The study will include healthy children aged 3-6 years with at least one active, non-cavitated white spot lesion (ICDAS-II score 1 or 2). The study will be conducted at the Faculty of Dentistry, Alexandria University, with a total of 80 lesions randomly allocated to four parallel groups. The main questions it aims to answer are: Does Biomin fluoride varnish produce a different remineralizing effect compared with conventional 5% sodium fluoride varnish (Duraphat) after 6 months? Does adding 980-nm low-level diode laser irradiation to Biomin fluoride varnish or Duraphat improve the remineralization of white spot lesions compared with the corresponding varnish alone? Do the different treatments result in changes in lesion severity and activity, as assessed by ICDAS-II and DIAGNOdent readings? Do the treatments reduce the surface area of white spot lesions after 6 months? Researchers will compare four treatment groups to assess differences in remineralization: Group I (n=20): Biomin fluoride varnish (5% sodium fluoride incorporating bioactive glass). Group II (n=20): Biomin fluoride varnish combined with low-level diode laser. Group III (n=20): Duraphat 5% sodium fluoride varnish combined with low-level diode laser. Group IV (n=20): Duraphat 5% sodium fluoride varnish alone (control group). Participants will: Undergo baseline assessment of their white spot lesions using ICDAS-II visual-tactile examination, DIAGNOdent laser fluorescence, and standardized photographic assessment. Receive the randomly assigned fluoride varnish treatment, with diode laser irradiation applied to Groups II and III using a 980-nm diode laser. Return for follow-up assessments at 1, 3, and 6 months. At 3 months, the assigned varnish and laser treatment will be reapplied according to the group. Have lesion severity and activity assessed using ICDAS-II and changes in mineralization assessed through DIAGNOdent readings. At 6 months, standardized photographs will also be used to evaluate changes in lesion surface area. Follow post-treatment instructions, including avoiding fluoride-containing products on the day of varnish application and avoiding eating and drinking for at least 4 hours. The primary outcome is caries arrest/remineralization assessed through changes in lesion severity and activity using ICDAS-II and changes in mean DIAGNOdent readings at 1, 3, and 6 months. The secondary outcome is the change in white spot lesion surface area measured by standardized photographic assessment at 6 months.

Clinical Investigation of the Performance of Epinamel for Dental White Spot Lesions

Mintech-Bio Ltd is a UK-based start-up company which was created to turn 14 years of research from our co-founder Dr Alvaro Mata at Queen Mary University into a real-world product. Loss of tooth enamel from issues such as decay or erosion is a great cause of dental problems, affecting over half of people around the world. There is also evidence to suggest that having poor oral health may be connected to other health issues such as diabetes, heart problems, and lung infections like pneumonia. While treatments like fluoride varnishes and remineralization solutions can help with the effects of enamel loss, there's currently no easy-to-use option that actually regrows enamel in a way that closely matches the natural look and strength of real enamel. Mintech-Bio has created a special gel that helps rebuild tooth enamel back to its natural strength and structure. This new invention could take the place of fluoride treatments and make a big difference in preventing tooth problems around the world. The purpose of this research study is to demonstrate the efficacy of the Epinamel device in the treatment of dental white-spot lesions. If you meet all the screening criteria you will be entered into the study and shall have the device applied after the removal of dental braces. Each trial participant will have the treatment product applied to a tooth on one side of the mouth, and a comparative 'control' product named Curodont Repair (vVardis Professional, Switzerland will be applied on the opposite side of the mouth.

Orthodontic Treatment on Oral Microbiota and Salivary Proteins

Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited. Prior to orthodontic treatment, routine preoperative examinations will be conducted, informed consent forms will be signed, baseline oral conditions will be recorded, and oral and psychological-related questionnaires will be completed. Patients will be informed of the need for regular oral hygiene check-ups, caries risk assessments will be performed, and plaque, saliva, and intraoral photographs will be collected. During orthodontic treatment, plaque samples will be collected every 3 months, and saliva samples will be collected every 6 months until the treatment is completed to evaluate the changes in oral microbiota throughout the orthodontic process.

Remineralization Efficacy of Moringa Oleifera Varnish Vs MI Varnish in Initial Carious Lesions Over 6 Months Follow Up: a Randomized Controlled Clinical Trial

This randomized clinical trial aimed to test the remineralization effect of laboratory prepared Moringa Oleifera based varnish compared to MI varnish (CPP-ACP) on incipient carious lesions. The study could include any of the following participants: age: 25-35 years, males or females, presentation with at least one active WSLs on the study teeth at the start of the study, good oral hygiene, co-operative patients approving to participate in the trial, have sufficient cognitive ability to understand consent procedures. The main question it aims to answer is in patients with initial caries lesions will Moringa Oleifera varnish have same remineralization efficacy as MI Varnish after 6 months follow up? MI varnish will be used as a comparator as it has been shown in many studies to be superior to fluoride varnish with NaF alone in arresting early caries lesions. The active ingredient, CPP-ACP can slowly release, localize and stabilize amorphous calcium, phosphate, and fluoride on the enamel surface which aids in deep mineralization of white spot lesions.

Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting

The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot lesions. The main questions it aims to answer are: 1- Are Icon resin infiltration (RI) and Vanish™ XT varnish comparable in restoring esthetics of white spot lesions? Researchers will compare Resin infiltration to vanish xt varnish to see if they are effective in masking white spot lesions Participants will: * Have their white spot lesions treated in the dental clinic by the intervention methods * Visit the clinic after 1 month, 3 months and 6 months to assess the restorations objectively and subjectively